|
KMID : 1188320170110040567
|
|
Gut and Liver
2017 Volume.11 No. 4 p.567 ~ p.573
|
|
|
Efficacy of a Multiplex Paclitaxel Emission Stent Using a Pluronic® Mixture Membrane versus a Covered Metal Stent in Malignant Biliary Obstruction: A Prospective Randomized Comparative Study
|
|
Jang Sung-Ill
Lee Se-Joon
Jeong Seok
Lee Don-Haeng
Kim Myung-Hwan
Yoon Hong-Jin
Lee Dong-Ki
|
|
|
Abstract
|
|
|
Background/Aims: A drug-eluting stent for unresectable malignant biliary obstruction was developed to increase stent patency by preventing tumor ingrowth. The safety and efficacy of a new generation of metallic stents covered with a paclitaxel-incorporated membrane using a Pluronic® mixture (MSCPM-II) were compared prospectively with those of covered metal stents (CMSs) in patients with malignant biliary obstructions.
Methods: This study was initially designed as a prospective randomized trial but was closed early because of a high incidence of early occlusion. Therefore, the data were analyzed using the intent-to-treat method. A total of 72 patients with unresectable distal malignant biliary obstructions were prospectively enrolled.
Results: The two groups did not differ significantly in basic characteristics and mean follow-up period (MSCPM-II 194 days vs CMS 277 days, p=0.063). Stent occlusion occurred in 14 patients (35%) who received MSCPM-II and in seven patients (21.9%) who received CMSs. Stent patency and survival time did not significantly differ between the two groups (p=0.355 and p=0.570). The complications were mild and resolved by conservative management in both groups.
Conclusions: There were no significant differences in stent patency or patient survival in MSCPM-II and CMS patients with malignant biliary obstructions.
|
|
|
KEYWORD
|
|
|
Drug-eluting stents, Biliary tract neoplasms, Pancreatic neoplasms, Self expandable metallic stents
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
   
|